Efficient asymmetric synthesis of trifluoromethylated β-aminophosphonates and their incorporation into dipeptides.
نویسندگان
چکیده
Addition of anions derived from dialkyl methylphosphonates to (Ss)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine afforded (Ss,R) addition adducts in moderate to good yield (53-75%) with excellent diastereoselectivity (94-95% de). After selective removal of the N-sulfinyl group, dipeptides containing enantiomerically pure diethyl 2-amino-3,3,3-trifluoropropylphosphonate were synthesized to investigate the influence of the trifluoromethyl substituent on N-terminal coupling.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 94 شماره
صفحات -
تاریخ انتشار 2012